MUCOSAL BOOSTING FOLLOWING PARENTERAL PRIMING

摘要

PROBLEM TO BE SOLVED: To provide compositions and methods for enhancing mucosal and systemic immunity to various antigens, including the pathogens or cancers, having or not having effective vaccines and/or treatments at present.SOLUTION: The method for bringing an immune response in a subject includes steps of: (a) parenterally administering a first immunogenic composition comprising one or more polypeptide antigens and; and (b) mucosally administering a second immunogenic composition comprising one or more antigens, thereby inducing an immune response in the subject.