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H. pylori growth inhibitor containing a derivative of N- acetyl glucosamine

机译:幽门螺杆菌生长抑制剂,含有N-乙酰基葡糖胺衍生物

摘要

PROBLEM TO BE SOLVED: To provide a Helicobacter pylori proliferation inhibitor which contains simply and massively produced compound and specifically inhibits proliferation of the Helicobacter pylori, safe and not producing a resistant bacteria.;SOLUTION: The Helicobacter pylori inhibitor comprises N-acetylglucosamine and either of an N-acetylglucosamine α-linked monosaccharide derivative represented by formula (1) or an N-acetylglucosamine α-linked oligosaccharide derivative represented by formula (2). Formula (1); GlcNAc1-α-O-Y. (Y is a (substituted) aromatic ring-containing group, an acyl group in the formula). Formula (2); GlcNAc1-α-Gal-Z. (Z is a terminal hydrogen atom, a 1-8C alkoxyl group, a sugar chain, a peptide or a lipid, in the formula.).;COPYRIGHT: (C)2007,JPO&INPIT
机译:解决的问题:提供一种幽门螺杆菌增殖抑制剂,其包含简单且大量生产的化合物,并特异性抑制幽门螺杆菌的增殖,安全且不产生抗药性细菌。式(1)表示的N-乙酰氨基葡萄糖α-连接的单糖衍生物或式(2)表示的N-乙酰氨基葡萄糖α-连接的寡糖衍生物。公式1); GlcNAc 1-α-O-Y。 (Y为(取代的)含芳环基团,式中的酰基)。公式(2); GlcNAc 1-α-Gal-Z。 (式中,Z为末端氢原子,1-8C烷氧基,糖链,肽或脂质。);版权所有:(C)2007,JPO&INPIT

著录项

  • 公开/公告号JP5140246B2

    专利类型

  • 公开/公告日2013-02-06

    原文格式PDF

  • 申请/专利权人 公益財団法人野口研究所;

    申请/专利号JP20060070727

  • 申请日2006-03-15

  • 分类号A61K31/7036;A61K31/7034;A61K31/7008;A61K31/7028;A61P31/04;A61P1/04;C07H15/203;C07H13/06;C07H15/18;C07H3/04;

  • 国家 JP

  • 入库时间 2022-08-21 16:53:15

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