Oral Administration of N-acetyl-D Glucosamine Polymer Particles Down- Regulates Airway Allergic Responses; Annual rept. 24 Feb 2007-23 Apr 2008

摘要

This is an annual report of the 5th grant year. PI and 2 Research Associates moved to the current Institute in 2003 from East Carolina University. The project was re-started in December 2004 with approval of no- cost extension until 5/23/2009. In this grant period, we established a method producing chitin particles at 10 100 gram per batch. Biological activities to induce IL- 12 and TNFalpha in vitro and to down-regulate allergic responses in mice were tested and the product was qualified for the purpose. We are continued to establish a method for larger scale of production at 500 1,000 gram per batch. We also realized that several experiments in 2006 2007 might not be reliable due to some mice that were later found being infected with Helicobacter spp. These experiments will be re-examined.