Evaluation kit evaluation method and substance, the screening method of the substance, as well as determination kit and method of determining the risk of developing or future existence of the onset of diabetic nephropathy

摘要

Providing a set of technologies for identifying new biomarkers that reflect the risk of future diabetic nephropathy, using the biomarker. By ingestion of the test substance to the animal risk of future higher animal or develop diabetic nephropathy, and compared with a reference value for the concentration of the at least one marker substance eight in the body fluids of the animal, the test substance I will evaluate the effect of reducing the risk of future or improvement of diabetic nephropathy with is. It is also possible to capture the marker substance to a carrier which is immobilized a substance having an affinity for the marker substance, to calculate the concentration of the marker substance in a body fluid. Screening method for a substance using the evaluation method, and is also provided method of determining the risk of developing or future existence of the onset of diabetic nephropathy, which was used as an indicator the marker substance.