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Methods and Compositions for Generation of Induced Pluripotent Stem Cells By RNAA
Methods and Compositions for Generation of Induced Pluripotent Stem Cells By RNAA
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机译:通过RNAA产生诱导的多能干细胞的方法和组成
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摘要
The present disclosure provides methods for inducing somatic cells to form induced pluripotent stem (iPS) cells. The method includes introducing a small activating RNA (saRNA) molecule into the somatic cell, where the saRNA molecule increases transcription of a transcription factor that induces the formation of induced pluripotent stem cells. The present disclosure also provides compositions and kits comprising a saRNA molecule that increases transcription of a transcription factor that induces the formation of induced pluripotent stem cells. The present disclosure provides iPS cells comprising at least one exogenous saRNA molecule, where the saRNA molecule increases transcription of a transcription factor that induces the formation of induced pluripotent stem cells.
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