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Methods for Altering MRNA Splicing and Treating Familial Dysautonomia and Other Mechanistically Related Disorders
Methods for Altering MRNA Splicing and Treating Familial Dysautonomia and Other Mechanistically Related Disorders
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机译:改变MRNA剪接和治疗家族性自主神经和其他机械相关疾病的方法
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摘要
This invention relates to methods for altering the splicing of mRNA in cells. In particular, this invention also relates to methods for increasing the ratio of wild type to misspliced forms of mRNA and corresponding encoded proteins in cells possessing a mutant gene encoding either the i) misspliced mRNA corresponding to the mutant protein or ii) a component in the splicing machinery responsible for processing the misspliced mRNA. In addition, this invention relates to treating individuals having a disorder associated with a misspliced mRNA, such as Familial Dysautonomia or Neurofibromatosis 1, by administering to such an individual a cytokinin such as kinetin.
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