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METHODS FOR BLOCKING CELL PROLIFERATION AND TREATING DISEASES AND CONDITIONS RESPONSIVE TO CELL GROWTH INHIBITION

机译:阻止细胞增殖和治疗与细胞生长抑制反应有关的疾病和状况的方法

摘要

In alternative embodiments, the invention provides methods for regulating or modulating RAF kinases. In alternative embodiments, the invention provides methods for ameliorating, preventing and/or treating diseases, infections and/or conditions having unwanted, pathological or aberrant cell proliferation, or that are responsive to inhibition or arrest of cell growth, by administration of an allosteric RAF inhibitor and/or any agent which prevents localization of RAF to mitotic spindles or mid-bodies.
机译:在替代实施方案中,本发明提供了用于调节或调节RAF激酶的方法。在替代实施方案中,本发明提供了通过施用变构RAF来改善,预防和/或治疗具有不希望的,病理性或异常的细胞增殖或响应于抑制或阻止细胞生长的疾病,感染和/或病状的方法。抑制剂和/或任何阻止RAF定位于有丝分裂纺锤体或中体的试剂。

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