embedded image or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor."/> Tetrahydroquinolinyl compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof
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Tetrahydroquinolinyl compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof

机译:抑制类香草酸受体1亚型(VR1)受体的四氢喹啉基化合物及其用途

摘要

Compounds that are antagonists of the VR1 receptor, having formula (I); embedded image or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.
机译:为VR1受体的拮抗剂,具有式(I)的化合物; “嵌入式图像” 或其药学上可接受的盐,前药或前药盐,其中A 1 ,A 2 ,A 3 ,A 4 ,R 7 ,R 8 ,R 9 ,X,Y,Z,L,n和m是如本文所定义,其可用于通过抑制VR1受体预防或改善的疾病。

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