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MicroRNA as a cancer progression predictor and its use for treating cancer

机译：MicroRNA作为癌症进展的预测因子及其在治疗癌症中的用途

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摘要

The present invention is based on the findings that a novel function for miR142-3p in the regulation of Sox2, adenylyl cyclase 9 (AC9), and CD133 expressions, and consequently the overall stemness of recurrent GBM cells as well as CSCs, and that miR142-3p modulated tumor-initiating properties in recurrent GBM. The present invention consequently supports the development of novel miRNA-based strategies for brain tumor treatment.

机译：本发明基于以下发现：miR142-3 p 在调节Sox2，腺苷酸环化酶9（AC9）和CD133表达以及因此复发的GBM细胞的总体干性方面具有新功能。以及CSC，以及miR142-3 p 调节了复发性GBM中的肿瘤起始特性。因此，本发明支持用于脑肿瘤治疗的新的基于miRNA的策略的发展。 展开▼

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公开/公告号US8404437B2

专利类型

公开/公告日2013-03-26

原文格式PDF

申请/专利权人 SHIH-HWA CHIOU;GUANG-YUH CHIOU;
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申请/专利号US201113074719

发明设计人 SHIH-HWA CHIOU;GUANG-YUH CHIOU;
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申请日2011-03-29

分类号C12Q1/68;C07H21/02;C07H21/04;

国家 US

入库时间 2022-08-21 16:45:07

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