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MicroRNA as a cancer progression predictor and its use for treating cancer

机译：MicroRNA作为癌症进展的预测因子及其在治疗癌症中的用途

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摘要

The present invention is based on the findings that a novel function for miR142-3p in the regulation of Sox2, adenylyl cyclase 9 (AC9), and CD133 expressions, and consequently the overall stemness of recurrent GBM cells as well as CSCs, and that miR142-3p modulated tumor-initiating properties in recurrent GBM. The present invention consequently supports the development of novel miRNA-based strategies for brain tumor treatment.

机译：本发明基于以下发现：miR142-3p在调节Sox2，腺苷酸环化酶9（AC9）和CD133的表达中具有新功能，因此在复发性GBM细胞以及CSC中具有整体干性，而miR142复发性GBM中-3p调节的肿瘤起始特性。因此，本发明支持用于脑肿瘤治疗的新的基于miRNA的策略的发展。

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公开/公告号US9107934B2

专利类型
公开/公告日2015-08-18

原文格式PDF
申请/专利权人 TAIPEI VETERANS GENERAL HOSPITAL;
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申请/专利号US201213725586
发明设计人 SHIH-HWA CHIOU;GUANG-YUH CHIOU;
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申请日2012-12-21
分类号A61K48;C07H21/02;C07H21/04;C12N15/63;A61K31/7088;C12N15/113;
国家 US
入库时间 2022-08-21 15:22:30

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