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Combined preparation of a thiazide diuretic and a loop diuretic
Combined preparation of a thiazide diuretic and a loop diuretic
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机译:噻嗪类利尿剂和loop利尿剂的联合制备
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摘要
The specific molecular basis of the interaction between talin and integrin β3 has been defined. This specific interaction provides a new therapeutic target; agents that can disrupt this specific interaction should be useful therapeutic agents for a number of significant diseases and conditions including inflammation, heart disease, including myocardial infarction, and tumor metastasis. The present invention includes a chimeric peptide that has high affinity for talin, muteins of talin and integrin β3 as well as screening methods for agents that can disrupt the interaction between talin and integrin β3.
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