Decreased Diuresis in Response to a Thiazide Diuretic at a Simulated Altitude

摘要

The effect of hydrochlorothiazide on the diuretic response of rats at 12,000 ft. was examined. After administration of a saline load, with and without drug, urine was collected over a 5-hr. period at both altitude and ground level. Total volume, urinary Na(+) and K(+), and pH were determined. The most pronounced effect of the altitude-drug interaction was decrease in the expected urine volume while the increased Na(+) output did not change from the observed with the drug at ground level. The results are discussed in relation to the possible basis for the observed phenomenon. (Author)