首页> 外国专利> Compound having structure derived from mononucleoside or mononucleotide, nucleic acid, labeling substance, and method and kit for detection of nucleic acid

Compound having structure derived from mononucleoside or mononucleotide, nucleic acid, labeling substance, and method and kit for detection of nucleic acid

机译:具有衍生自单核苷或单核苷酸的结构的化合物,核酸,标记物质以及用于核酸检测的方法和试剂盒

摘要

The present invention provides, for example, a labeling substance that allows the double helix structure of a nucleic acid to be detected effectively. The present invention provides a compound having a structure derived from mononucleoside or mononucleotide, with the structure being represented by the following formula (1), (1b), or (1c), a tautomer or stereoisomer thereof, or a salt thereof.; embedded image ;In the above formulae, B is an atomic group having a nucleobase skeleton, E is an atomic group having a deoxyribose skeleton, a ribose skeleton, or a structure derived from either one of them, or an atomic group having a peptide structure or a peptoid structure, and Z11 and Z12 each are a hydrogen atom, a protecting group, or an atomic group that exhibits fluorescence and may be identical to or different from each other.
机译:本发明提供例如一种标记物质,其可以有效地检测核酸的双螺旋结构。本发明提供一种具有衍生自单核苷或单核苷酸的结构,且其结构由下式(1),(1b)或(1c)表示的化合物,其互变异构体或立体异构体或其盐。 “嵌入式图像” 上式中,B是具有核碱基骨架的原子团,E是具有脱氧核糖骨架,核糖骨架或它们之一衍生的结构的原子团,或具有肽结构或a的原子团。类肽结构,Z 11 和Z 12 分别是一个氢原子,一个保护基或一个原子团,它们表现出荧光并且可以彼此相同或不同。

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