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Anti-MET monoclonal antibody, fragments and vectors thereof, for the treatment of tumors and corresponding products

机译：抗 MET 单克隆抗体，其片段和载体，用于治疗肿瘤和相应的产品

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摘要

Use of a monoclonal antibody directed against the extracellular domain of hepatocyte growth factor is disclosed for the preparation of a medicament for the treatment of tumors and/or metastases and of a diagnostic tool for detecting neoplastic cells as well as vectors comprising at least a portion of the nucleotide sequence encoding the anti-Met monoclonal antibody, products containing the anti-Met monoclonal antibody and/or at least one fragment thereof and at least one kinase inhibitor. 展开▼

机译：公开了针对肝细胞生长因子的胞外域的单克隆抗体在制备用于治疗肿瘤和/或转移的药物以及用于检测赘生性细胞的诊断工具以及包含至少一部分肝癌细胞的载体中的用途。编码抗Met单克隆抗体的核苷酸序列，包含抗Met单克隆抗体和/或其至少一个片段和至少一种激酶抑制剂的产物。展开▼

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公开/公告号US8388958B2

专利类型

公开/公告日2013-03-05

原文格式PDF

申请/专利权人 PAOLO MARIA COMOGLIO;ELISA VIGNA;SILVIA GIORDANO;
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申请/专利号US20070223623

发明设计人 PAOLO MARIA COMOGLIO;ELISA VIGNA;SILVIA GIORDANO;
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申请日2007-02-05

分类号A61K39;

国家 US

入库时间 2022-08-21 16:42:53

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1. 治疗肿瘤的抗Met单克隆抗体及其片段和载体及相应产品 [P] . 中国专利： CN101379192B . 2013.07.31

2. 治疗肿瘤的抗Met单克隆抗体及其片段和载体及相应产品 [P] . 中国专利： CN101379192A . 2009-03-04

3. monoclonal antibody or binding fragment, isolated nucleic acid molecule, vector, host cell, methods for preparing the monoclonal antibody or binding fragment in vivo or in vitro and for prevention and / or treatment and / or adjuvant therapy and / or diagnosis of a tumor, conjugate, kit, use of a monoclonal antibody or binding fragment, and pharmaceutical composition? [P] . BR112017002080A2 . 2018-02-27

机译：单克隆抗体或结合片段，分离的核酸分子，载体，宿主细胞，体内或体外制备单克隆抗体或结合片段以及预防和/或治疗和/或辅助治疗和/或诊断肿瘤的方法，偶联物，试剂盒，单克隆抗体或结合片段的用途以及药物组合物？

4. ANTI-MET MONOCLONAL ANTIBODY, FRAGMENTS AND VECTORS THEREOF, FOR THE TREATMENT OF TUMORS AND CORRESPONDING PRODUCTS [P] . CY1111884T1 . 2015-11-04

机译：抗金属单克隆抗体，其片段和载体，用于治疗肿瘤和相应产品

5. ANTI-MET MONOCLONAL ANTIBODY, FRAGMENTS AND VECTORS THEREOF, FOR THE TREATMENT OF TUMORS AND CORRESPONDING PRODUCTS [P] . CA2638889C . 2015-06-02

机译：抗金属单克隆抗体，其片段和载体，用于治疗肿瘤和相应产品

1. ANTITUMOR EFFECTS OF MONOCLONAL ANTIBODY FAB′ FRAGMENT CONTAINING IMMUNOCONJUGATES [J] . 刘小云, 甄永苏中国医学科学杂志（英文版） . 2002,第001期

2. Highly Sensitive and Specific Monoclonal Antibody-Based Serological Methods for Rice Ragged Stunt Virus Detection in Rice Plants and Rice Brown Planthopper Vectors [J] . LIU Huan, SONG Xi-jiao, NI Yue-qun, 农业科学学报：英文版 . 2014,第009期

3. Highly Sensitive and Speciifc Monoclonal Antibody-Based Serological Methods for Rice Ragged Stunt Virus Detection in Rice Plants and Rice Brown Planthopper Vectors [J] . WU Jian-xiang 农业科学学报（英文版） . 2014,第009期

4. COMPARISON OF FOUR METHODS TO GENERATE IMMUNOREACTIVE FRAGMENTS OF A MURINE MONOCLONAL ANTIBODY OC859 AGAINST HUMAN OVARIAN EPITHELIAL CANCER ANTIGEN [J] . 邹颖, 卞美璐, 杨子义, 中国医学科学杂志：英文版 . 1995,第002期

5. EGFR gene copy number as a predictive biomarker for resistance to anti-EGFR monoclonal antibodies in metastatic colorectal cancer treatment: a meta-analysis [J] . Wei-Dong Shen, Hong-Lin Chen, Peng-Fei Liu 中国癌症研究（英文版） . 2014,第001期

6. Validation and comparison of anti-αvβ3 and anti-αvβ5 rabbit monoclonal versus murine monoclonal antibodies in four different tumor entities [J] . B?gerC., KalthoffH., GoodmanS.L., Applied immunohistochemistry and molecular morphology: AIMM . 2013,第6期

7. Monoclonal antibodies and antibody fragments: state of the art and future perspectives in the treatment of non-haematological tumors. [J] . Di Fede G, Bronte G, Rizzo S, Expert opinion on biological therapy . 2011,第11期

8. Expression of a human monoclonal anti-(rhesus D) Fab fragment in Escherichia coli with the use of bacteriophage λ vectors [J] . D R Burton, M A A Persson, R A Williamson The biochemical journal . 1991,第2期

9. Using Hydrophilic Interaction Chromatography - Mass Spectrometry for Heightened Product Characterization to Overcome Challenges with Hydrophobic Antibody Drug Conjugates and Monoclonal Antibodies [C] . Jacquelynn Smith, Matthew A. Lauber, Stephan M. Koza, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

10. Fab fragments of monoclonal antibodies directed against HER2 /neu or tumor-associated glycoprotein-72 for radioimmunodetection of breast cancer [D] . Tang, Ying 2005

11. Expression of a human monoclonal anti-(rhesus D) Fab fragment in Escherichia coli with the use of bacteriophage lambda vectors. [O] . R A Williamson, M A Persson, D R Burton 1991

12. Monoclonal antibodies and antibody fragments: state of the art and future perspectives in the treatment of non-haematological tumors [O] . Di Fede G, Bronte G, Rizzo S, 2011

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