monoclonal antibody or binding fragment, isolated nucleic acid molecule, vector, host cell, methods for preparing the monoclonal antibody or binding fragment in vivo or in vitro and for prevention and / or treatment and / or adjuvant therapy and / or diagnosis of a tumor, conjugate, kit, use of a monoclonal antibody or binding fragment, and pharmaceutical composition?

摘要

The present invention belongs to the fields of tumor treatment and molecular immunology and provides an anti-ctla4 monoclonal antibody or antigen binding fragment thereof, a medicinal composition thereof and a use thereof. The monoclonal antibody of the present invention prevents clta4 from binding to b7, thereby eliminating the immunosuppressive effect of ctla4 in the host and activating t lymphocytes.