首页>
外国专利>
Antibodies with immune effector activity and that internalize in endosialin-positive cells
Antibodies with immune effector activity and that internalize in endosialin-positive cells
展开▼
机译:具有免疫效应子活性并在内皮唾液酸蛋白阳性细胞中内在化的抗体
展开▼
页面导航
摘要
著录项
相似文献
摘要
This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and have the ability in the alternative to become internalized by cells expressing endosialin and to induce an immune effector activity such as antibody-dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to endosialin-expressing cells as well as in eliciting an immune-effector activity particularly on tumor and neovascular cells and precursors. The invention is also related to nucleotides encoding the antibodies of the invention, cells expressing the antibodies; methods of detecting cancer and neovascular cells; and methods of treating cancer and neovascular disease using the antibodies, derivatives and fragments.
展开▼