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Jasmonate based assays for identifying compounds that selectively inhibit mitochondrial bound hexokinases
Jasmonate based assays for identifying compounds that selectively inhibit mitochondrial bound hexokinases
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机译:基于茉莉酸酯的检测方法,用于鉴定可选择性抑制线粒体结合己糖激酶的化合物
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摘要
The present invention provides compositions comprising compounds that selectively bind to hexokinases thereby promoting dissociation of these enzymes from mitochondria, and methods of use of such compounds and compositions to induce cell death in diseases and disorders characterized by the high levels of mitochondrial bound hexokinase. The present invention further discloses methods and assays for detecting and identifying molecules having these activities.
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