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Ricin A chain mutants lacking enzymatic activity as vaccines to protect against aerosolized ricin
Ricin A chain mutants lacking enzymatic activity as vaccines to protect against aerosolized ricin
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机译:蓖麻毒素A链突变体缺乏酶活性,可作为疫苗预防雾化蓖麻毒蛋白
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摘要
The present invention provides methods to produce toxoid vaccines, such as ricin A chain vaccines, with reduced ability to promote vascular leak syndrome (VLS) and catalytic toxicity associated with various proteinaceous toxins, such as ribosome inactivating proteins. The invention also provides toxoids which have been mutated to lack amino acid sequences which induce VLS and toxic catalytic activity.
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