Design of active Proteins BMP antagonists, such as serine / Threonine Kinase receptors Type I and Type II

摘要

A protein BMP Design comprising at least a mutation in at least one binding domain of the Receptor Type 1 or type II, where the mutation confers altered receptor binding of BMP Type I or type II receptor binding compared with Type 1 or type II by u BMP na corresponding wild type.The Protein according to claim 1, wherein the Protein is selected from the group consisting of BMP2, Bmp4, BMP6, BMP7, line with BPM5, these bmp8 and bmp9. Protein according to claim 1 which comprises at least a mutation within the Union:. Domain of Type IIB. The B domain of Union type IIC. The Domain of Type 1 yd Union; any combination of the above.An Osteogenic Protein Design comprising an Amino Acid Sequence which comprises at least a mutation in at least one binding domain of the Receptor Type 1 or type II, where the Union mutation confers altered BMP Receptor Type 1 or type II compared with the Uni The receptor type 1 or type II by BMP2 wild type.