首页>
外国专利>
THE USE OF A BMP PROTEIN RECEPTOR COMPLEX FOR SCREENING BONE METABOLISM ACTIVES AND CELLS CO-TRANSFECTED WITH A TYPE II BMP RECEPTOR AND A TYPE I BMP RECEPTOR
THE USE OF A BMP PROTEIN RECEPTOR COMPLEX FOR SCREENING BONE METABOLISM ACTIVES AND CELLS CO-TRANSFECTED WITH A TYPE II BMP RECEPTOR AND A TYPE I BMP RECEPTOR
展开▼
机译:BMP蛋白受体复合物在筛选与II型BMP受体和I型BMP受体共转染的骨代谢活性和细胞中的用途
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to a method for determining whether a compound is capable of binding to a BMP receptor kinase protein complex, the method comprising introducing a sample comprising the compound to the BMP receptor kinase protein complex and allowing the compound to bind to the BMP receptor kinase protein complex, wherein the BMP receptor kinase protein complex is comprised of a BMP type I receptor kinase protein and the BMP receptor kinase protein BRK-3. The invention further relates to a method for determining the concentration of a BMP receptor ligand in a clinical sample, the method comprising introducing the sample comprising the ligand to a BMP receptor kinase protein complex and allowing the ligand to bind to the BMP receptor kinase protein complex, wherein the BMP receptor kinase protein complex is comprised of a BMP type I receptor kinase protein and BMP receptor kinase protein BRK-3. The invention further relates to a host cell co-transfected with an expression vector comprising a DNA sequence that codes for the BMP receptor kinase protein BRK-3 and an expression vector comprising a DNA sequence that codes for a BMP type I receptor kinase protein. The invention further relates to a host cell co-transfected with an expression vector comprising a DNA sequence that codes for a soluble or incomplete BMP type I receptor kinase protein and a soluble or incomplete BMP receptor kinase protein BRK-3. The invention further relates to a method for determining whether a test compound produces a signal upon binding to a BMP receptor protein complex.
展开▼