Tritium-labeled hyaluronic acid, method of labeling hyaluronic acid by tritium and use thereof

摘要

the invention relates to acid, hyaluronic acid znacenu00e9 tritium and ways of its preparation.the procedure is based on oxidacne - redukcnu00ed strategy where the oxidation to the aldehyde and reduced back to alcohol is in position 6 of part of the polysaccharide.the result is a native molecular weight in the range of 800 derivative g.mol.sup. -1.n.az 1 000 000 g.mol.sup. - 1.n.the high stability and specific activity which is limited only by the specific activity of pouzitu00e9ho redukcnu00edho cinidla.the preparation is a quick, cheap and produces a minimum of radioactive waste in the form of an ballast.znacenu00e1 hyaluronic acid was tested in studies of biodistribution in potkanu where she was overena stability detection of hyaluronic acid after intravenous administration in power.znacenu00e1 hyaluronic acid can use in biomedical applications.