首页> 外国专利> Use of copper complexes containing 2-phenyl-3-hydroquinolin-4(1H)-one and derivatives of 1,10-fenanthrolin for preparing medicaments intended for treating tumor diseases

Use of copper complexes containing 2-phenyl-3-hydroquinolin-4(1H)-one and derivatives of 1,10-fenanthrolin for preparing medicaments intended for treating tumor diseases

机译:含有2-苯基-3-氢喹啉-4(1H)-one和1,10-菲咯啉衍生物的铜配合物在制备用于治疗肿瘤疾病的药物中的用途

摘要

pouzitu00ed complex loop in oxidacnu00edm degree + ii and their krystalosolvu00e1tu of general formula [cu (qui) (r.sub.n.n.phen)] x, vyju00e1drenu00fdch structural formula (i), where the symbol qui represents 2 - phenyl - 3 - benzoic acid - 4 (1h) - onu00e1tovu00fd aniont, symbol r.sub.n.n.where n = 1 to 4, a non or substituents on 1,10 - fenanthrolinu (phen), where r1 is selected from the group of non hydrogen, 4 - methyl, 5 - methyl 5 nitro, 5 -], and / or if r1 5 methylthen r2 6 methyl 4 -, where r1 is phenyl, r2 7 - phenyl, where r1 3 - methyl, r2 is 4 - methyl, r3 is methyl and r4 is 7 - 8 - methyl, vyju00e1drenu00e9 specific formula [cu (qui) (4 - methylphen)] x,[cu (qui) (5 - methylphen)] x, [cu (qui) (5 - methylphen)] x, [cu (qui) (5 - nitrophen)] x, [cu (qui) (5 - chlorophen)] x, [cu (qui) (5.6 - dimethylphen)] x [cu (qui) (4.7 - difenylphen)] x, [cu (qui) (3,4,7,8 - tetramethylphen)] xwhere the symbol x is selected from the group of monoaniont acid: f.sup. -.n., cl.sup. -.n., br.sup. -.n., i.sup. -.n., no.sub.3.n..sup. -.n., bf.sub.4.n..sup. -.n., bph.sub.4.n..sup. -.n., hcoo.sup. -.n., ch.sub.3.n.coo.sup. -.n., clo.sub.4.n..sup. -.n., hso.sub.4.n..sup. -.n.,for the solution lu00e9civ for lung cancer treatment and / or for the treatment of malignant melanoma and / or for the treatment of deloznu00edho cu00edpku and / or cancer vajecnu00edku and / or cisplatin - resistant human tumour lines nowe of vajecnu00edku and / or for the treatment of prostate cancer.
机译:氧化还原度为ii的pouzit复杂环及其通式[cu(qui)(r.sub.nnphen)] x,vyj u00e1dren u00fdch结构式(i)的krystalosolv u00e1tu,其中符号qui表示2-苯基-3-苯甲酸-4(1h)-在阴离子上,符号r.sub.nn,其中n = 1至4,在1,10-泛蒽啉(phen)上为非或取代基,其中r1选自非氢,4-甲基,5-甲基5硝基,5-]和 /或r1 5甲基,则r2 6甲基4--,其中r1为苯基,r2 7-苯基,其中r1 3-甲基,r2是4-甲基,r3是甲基,r4是7-8-甲基,vyj u00e1dren u00e9特定公式[cu(qui)(4-methylphen)] x,[cu(qui)(5 -(methylphen)] x,[cu(qui)(5- -methylphen)] x,[cu(qui)(5--nitrophen)] x,[cu(qui)(5--chlorophen)] x,[cu(qui) (5.6-二甲基苯)] x [cu(qui)(4.7-二苯并菲)] x,[cu(qui)(3,4,7,8-四甲基苯)] x其中,符号x选自单阴离子酸:一口-.n。,cl.sup。 -.n。,br.sup。 -.n。,i.sup。 -.n。,编号sub.n..sup。 -.n。,bf.sub.4.n..sup。 -.n。,bph.sub.4.n..sup。 -.n。,hcoo.sup。 -.n。,ch.sub.3.n.coo.sup。 -.n。,clo.sub.n..sup。 -.n。,hso.sub.n..sup。 -.n。,用于治疗肺癌和/或治疗恶性黑色素瘤和//或治疗恶性黑色素和//或治疗癌症的溶液l / u或抗顺铂耐药的人类肿瘤细胞系和/或用于治疗前列腺癌。

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