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Identification of molecules that modulate protein-protein interactions using protease-activated reporters
Identification of molecules that modulate protein-protein interactions using protease-activated reporters
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机译:使用蛋白酶激活的报道分子鉴定可调节蛋白质-蛋白质相互作用的分子
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摘要
Methods and assays for identifying a compound that modulates a protein-protein interaction between a first and a second protein. The methods and assays require a protease that is attached to the second protein and a split and rearranged reporter activating protein that is attached to the first protein, wherein the reporter activating protein comprises a cleavage site for the protease that is interposed between two portions of the reporter activating protein and wherein the two portions of the reporter activating protein are in a rearranged order.
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