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METHOD, CONNECTION, PHARMACEUTICAL COMPOSITION AND MEDICINE FOR RESTORING DAMAGED MEMORY IN NORM AND PATHOLOGY

机译:恢复正常和病理中受损记忆的方法,连接,药物成分和药物

摘要

The invention relates to a method for recovering memory lost as a result of pathology, adverse effects or time. The method includes the introduction of an effective amount of (azaheterocyclyl) alkyl derivatives of amides of (het) arylglycines of the general formula I in which n and m can be 0, 1, 2 and 3; the sign (#) hereinafter indicates the possibility of a chiral center; R is an optionally substituted C-Caryl or 5-7 membered hetaryl containing 1-3 heteroatoms selected from nitrogen, oxygen and sulfur, optionally fused to a benzene ring; A1 and A2 independently represent an optionally substituted 3-7 membered saturated, partially saturated or aromatic azaheterocycle containing from 1 to 3 nitrogen atoms in the ring and optionally fused to a benzene ring; or their pharmaceutically acceptable salts or alkyl esters in the form of individual optical isomers or mixtures thereof. The invention also relates to compounds of the general formula I, a pharmaceutical composition and a medicament based thereon. The effective dose, as a rule, is 0.005-1.5 mg / kg body weight, preferably 0.005-1.0 mg / kg body weight, at least once a day for the period necessary to achieve a therapeutic effect.
机译:本发明涉及一种用于恢复由于病理,不良影响或时间而丢失的记忆的方法。该方法包括引入有效量的通式I的(杂)芳基甘氨酸的酰胺的(氮杂环基)烷基衍生物,其中n和m可以为0、1、2和3; n为1。以下的符号(#)表示存在手性中心的可能性。 R为任选取代的C-C芳基或含有1-3个选自氮,氧和硫的杂原子的5-7元杂芳基,其任选稠合至苯环; A1和A2独立地表示在环中含有1至3个氮原子并任选稠合至苯环的任选取代的3-7元饱和,部分饱和或芳族氮杂杂环;或其光学异构体或其混合物形式的它们的药学上可接受的盐或烷基酯。本发明还涉及通式I的化合物,药物组合物和基于其的药物。在达到治疗效果所必需的时间内,每天至少一次有效剂量通常为0.005-1.5mg / kg体重,优选0.005-1.0mg / kg体重。

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