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Antibodies binding to human insulin-like growth factor i receptor (igf-ir) and uses thereof for the manufacture of pharmaceutical compositions
Antibodies binding to human insulin-like growth factor i receptor (igf-ir) and uses thereof for the manufacture of pharmaceutical compositions
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机译:结合人胰岛素样生长因子i受体(igf-ir)的抗体及其在制备药物组合物中的用途
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摘要
An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-11 to IGF-IR which is characterized in that said antibody is a) is of IgGI isotype, b) shows a ratio of IC 50 values of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IGF-II to IGF-IR of 1:3 to 3:1,c) inhibits for at least 80% at a concentration of 5 nM IGF-IR phosphorylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody, andd) shows no IGF-IR stimulating activity measured as IGF-IR phosphorylation at a concentration of 10 µM in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody has improved properties in antitumor therapy.
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