NOVEL CEFUROXIME FORMULATIONS USING A BIO-POLYMER FROM LAGENARIA SICERARIA FOR BRAIN SPECIFICITY VIA EAR

摘要

The current invention disclose novelistic approach for formulating bionanoparticles of Cefuroxime using a biopolymer obtained from the fruit pulp of Lagenaria siceraria for ear to brain targeting. Biopolymer was isolated by non solvent addition, method and it was characterized for presence of - (-CH3) alkenes, (≡CH) alkynes, amines, (-NO2) nitro, alcohol and ether functional groups present in biopolymer. Prepared nanoparticles were suspended in gelling agent for ear to brain targeting. The study revealed that the formulations showed promising prolongability in drug release for a period of 32 hours apart from this it also showed promising emulsifying ability, retardability and film forming ability which was confirmed by suitable formulations. Conclusion was drawn that the formulating bionanoparticles can be used for ear to brain targeting and biopolymer can be used as bio excipient by formulating various drug delivery system.