thiadiazolo 3,4-h quinoline-7- carboxylic acids salts and esters processes for their preparation and their use as antiviral antiumor agents

摘要

The present invention relates to novel thiadiazoloquinolone derivative characterised in that the thiadiazoloquinolone is represented by general formula I and IA Wherein Z independently is a cyclopropyl ( formula IA) NHMe, OMe, p-(OH) C6H4 , P (MeO) C6H4, P(F)C6H4, o-(F) C6H4, 2.4-(F)2C6H4, where in R1 in COOR1 independently is an acid, an ester and or a salt Y1 and or Y2 are independently halogen and or H, in particular F, C or H, or Y2 is an at least one N comprising an heterocyclus or N(R2)2 and or a polymorph or a solvate of a thiadiazoloquinolone of formula I and IA.The present invention relates further to a process for the production of the thiadiazoloquinolone of formula I and IA, the use of a key precursor as well as their use as pharmaceutical active agents, in particular as agents that are active against cancer, as antibiotic and or at least one virus