Indolo2,3-b-, Indeno1,2-b- and Indeno2,1-bpyrido2,3-f quinoxaline-3-carboxylic acids and esters, processes for their preparation and their use as antiviral, antibiotic and antitumor agents

摘要

The present invention relates to novel quinoxaline derivatives represented by regioisomeric structures of quinoxalines of general formulas I and/or II,wherein the COOR¹ group independently is an acid, an ester and/or a salt, Y¹ and/or Y² are independently halogen and/or H, in particular Y¹ is fluorine, A is oxo (C=O), C(R³)₂ and/or N-R², wherein each R³ and/or R² independently are H, linear, branched or cyclic unsubstituted or substituted hydrocarbon and X¹ is H, halogen, linear, branched or cyclic unsubstituted or substituted hydrocarbon. The present invention relates further to a process for the production of the quinoxalines of formulas I and II, a key precursor as well as their use as pharmaceutical active agents, in particular as agents that are active against cancer, as antibiotic and/or at least one virus.