METHOD FOR MODIFYING THE PERMEABILITY OF DRUGS IN THE CORNEAL EPITHELIUM BY USING RETINOIDS AS MODULATORS OF TIGHT JUNCTIONS.

摘要

The invention provides methods for modifying the force of the tight junctions located between the corneal epithelium cells of mammals, preferably of human or species of veterinary interest, by using compounds selected from the retinoid family, the analogues and/or derivatives thereof, for allowing or facilitating the transepithelial penetration of the drug of ophthalmologic interest into the intraocular tissues.