Protein Domain Structure of Fibronectin that Bind interleukin (IL - 23) 23

摘要

Refers to a polypeptide that binds Interleukin 23 (IL - 23), with a sequence of amino acids at least 90% identical to the SEC ID no.: 60 - 100; comprising a Tenth Type III domain of Fibronectin (10fn3) which has at least one selected loop LOOP BC,Of FG and with an altered Amino Acid Sequence in the sequence of the corresponding Loop Domain 10fn3 Human; The amino acid sequence of the FG Loop BC, or is at least 80% identical to the SEC ID no: 2 - 59; Additionally, comprising one or more such Generic fractions As sialic acid, transferrin, seroalbumine,Among other Connector and a selected Group of amino acids cysteine gsgc SEC ID no.: eidkpcq SEC ID no. 101 and 102. It also relates to a Pharmaceutical composition. The polypeptide is useful for the treatment of autoimmune diseases