DITERPENE COMPOUNDS WITH ANTINEOPLASTIC ACTIVITIES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

摘要

The present invention provides a generic formulation of a family of novel diterpene compounds with antineoplastic activities. Contrary to existing pharmaceuticals used for anticancer treatment, the compounds exhibit extremely low toxicity, and, at therapeutical doses, even stimulate the proliferation of human lymphocytes. Compounds from the family have been found to show particularly selective cytotoxicity against several different cancer cell lines, while having immunostimulating effects on human lymphocytes. The compounds are useful in effective treatment of cancers, particularly leukemia.