ANTIBODY THAT SPECIFICALLY BINDS TO IgE/M1' AND INDUCES APOPTOSIS IN IgE-EXPRESSING B-CELLS

摘要

The invention relates to antibody that specifically binds an epitope in the M1' segment of IgE and induces apoptosis in IgE-expressing B-cells. The invention further relates to an isolated nucleic acid encoding the antibody, expression vector, host cell, process for producing the antibody, composition for the treatment of IgE-mediated disorders, method for preventing allergen-induced IgE production etc.