new sutures multi-functional, controlled release of antimicrobial substances, antibiotic, cicatrizzanti.

摘要

Object of the present invention is a method and the related production technology for the manufacturing of multifunctional suture threads with antimicrobial and/or antibiotic and/or cicatrizing properties that can be modulated as a function of the manufacturing conditions. The threads can display single properties or multiple properties among those described above. In particular, it was build up a technology that consider the melt incorporation of an antimicrobial and/or antibiotic and/or cicatrizing agent during the preparation of the suture threads. The spinning process is inline with the extrusion and by modulating the amount of agent, the drawing conditions (isothermal and non-isothermal), it is possible to regulate the final diameter, the mechanical resistance and the release of the necessary amount of agent over the space (i.e. locally in the proximity of the filament) and over the time (i.e. regulating the duration of the antimicrobial and/or antibiotic and/or cicatrizing activity) according to a precise linear function.