Silica nanoparticles for intracellular diffusion of poorly soluble bioactive agents

摘要

The present invention relates to a nanostructured material comprising silica nanoparticles, the surface of which is covered with anion groups and a bioactive agent linked by a hydrolyzable covalent bond, and optionally, PEG molecules, a fluorescent agent, a radionucleus and/or a substance that directs to specific receptors, cells or tissues, linked by a covalent bond. The invention also relates to the use thereof in the treatment or prophylaxis of a specific pathology.