Silica nanoparticles for intracellular diffusion of poorly soluble bioactive agents.

摘要

Silica nanoparticles for intracellular diffusion of poorly soluble bioactive agents.; The present invention relates to a nanostructured composite silica nanoparticles whose surface cover anionic groups and a bioactive agent linked by a hydrolysable covalent bond and optionally molecules of a PEG, a fluorescent agent, a radionuclide and / is or a substance principal receptor, specific cells or tissues, covalently bound, and their use in the treatment or prophylaxis of a specific pathology.