Coumarin derivatives substituted thiadiazole and their use as inhibitors of leukotriene biosynthesis

摘要

A compound of structural formula Iby their pharmaceutically acceptable salts and solvates, wherein: X is selected from -O- and -S-; R2 is selected from the group consisting of H, -OH, -F, C1-3 -alkyl , -OC 1-3 alkyl and -OC (O) C1-3alkyl; R3 is selected from the group consisting of -H, -C1-6alkyl, -C1-6alkyl substituted with one or morethan fluorine, -C1-6alkyl substituted with R9, C2-6 -alkenyl, C3-6 -cycloalkyl, C5-7 cycloalkenyl and -Z; R4 is selected from the group consisting of -H, -C1-6alkyl, -C1-6alkyl substituted with one másde or fluorine, -C1-6alkyl substituted with R9, C2-6 -alkenyl, C3-6 -cycloalkyl, C5-7- cycloalkenyl and -Z; or R3 and R4 together represent oxo; or R3 and R4 are attached together with the carbon to which they are attached to form a anilloseleccionado from the group consisting of a C3-6 cycloalkyl ring and C5-7 cycloalkenyl ring, with lacondición that when R3 and R4 are joined together with the coal or which they are attached by forming a cycloalkenyl ring C5-7, there is no double bond at the C-1 position of the ring, or R2, R3 and R4 are joined together with the carbon atom to which they are attached form a anillocicloalquenilo selected from **Formula**