Use of a lipopolysaccharide fraction of Vitreoscilla filiformis as an agent to stimulate the synthesis of skin antimicrobial peptides

摘要

Use of lipid A (I) of Vitreoscilla filiformis comprising tetrahydro-pyran compound (X), for the preparation of a composition to inhibit the proliferation of microbial flora, preferably undesirable skin bacteria, to prevent and/or treat microbial infections and superinfections of the skin, and to prevent the microbial proliferation in cell or organotypic culture, is claimed. Use of lipid A (I) of Vitreoscilla filiformis comprising tetrahydro-pyran compound of formula (X); when R is (PO(OH) 2) group, (I) comprises its inorganic salt, a primary, secondary or tertiary amine salt, or a phosphoethanolamine salt, for the preparation of a composition to inhibit the proliferation of microbial flora, preferably undesirable skin bacteria, to prevent and/or treat microbial infections and superinfections of the skin, before, simultaneously or after using the peeling agent, and to prevent the microbial proliferation in cell or organotypic culture, is claimed. AG 13-hydroxy decanoyl; AG 23-dodecanoyloxy decanoyl; R : H or PO(OR1a) 2; and R1a : H, 1-6C alkyl (optionally saturated), phenyl or benzyl ; An independent claim is included for a cosmetic process of skin peeling comprising simultaneously applying a peeling agent of the lipid A of Vitreoscilla filiformis. [Image] ACTIVITY : Dermatological; Antiseborrheic; Vulnerary; Fungicide; Antiinflammatory; Virucide; Antiulcer; Antidiabetic; Antibacterial; Antimicrobial. MECHANISM OF ACTION : None given.