thrombopoietin mimetic peptides that dimeric receptor bind MP1 and having thrombopoietic activity

摘要

A compound that binds to an mpl receptor comprising the structure TMP1- (L1) n-TMP2, wherein the C peptide tmp1 is connected to the C-terminus of TMP2 peptide by L1, and where tmp1 and TMP2 are selected each independently from the group nuclear compounds comprising the structure selected from the group consisting of: (a) X2-X3-X4-X5-X6-X7-X8-X9-X10, wherein X2 is selected from the group consisting of Glu, Lys , and Val; X3 is selected from the group consisting of Gly and Ala; X4 is Pro; X5 is selected from the group consisting of Thr and Ser; X6 is selected from the group consisting of Leu, Ile, Val, Ala, and Phe; X7 is selected from the group consisting of Arg and Lys; X8 is selected from the group consisting of Gln, Asn, and Glu; X9 is selected from the group consisting of Trp, Tyr, Cys, Ala, and Phe; X10 is selected from the group consisting of Leu, Ile, Val, Ala, Phe, Met, and Lys; (B) X2-X3-X4-X5-X6-X7-X8-X9-X10.