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TERNARY NON-LAMELLAR LIPID COMPOSITIONS OF STRUCTURE FORMING AMPHIPHILE, STRUCTURE SWELLING AMPHIPHILE AND DISPERSION STABILISING AMPHIPHILE
TERNARY NON-LAMELLAR LIPID COMPOSITIONS OF STRUCTURE FORMING AMPHIPHILE, STRUCTURE SWELLING AMPHIPHILE AND DISPERSION STABILISING AMPHIPHILE
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机译:结构形成AM,结构溶胀AM和分散稳定AM的三元非片状脂质组成
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摘要
The present invention provides a particulate composition including; a) at least 50 % of at least one structure forming amphiphile, b) 0 to 40 % of at least one structure swelling amphiphile, and c) 2 to 20 % of at least one dispersion stabilising polymeric amphiphile, where all parts are by weight relative to the sum of the weights of a+b+c and wherein the composition comprises non-lamellar particles or forms non-lamellar particles when contacted with an aqueous fluid. Where component b) is 0 % then component a) comprises at least two structure forming amphiphiles. The invention also provides pharmaceutical compositions of the compositions and kits containing the compositions for establishing a pharmaceutical formulation of an active agent.
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机译:本发明提供了一种颗粒组合物,包括: a)至少50%的至少一种结构形成两亲物,b)0至40%的至少一种结构溶胀性两亲物,以及c)2%至20%的至少一种稳定聚合物两亲物的分散体,其中所有份数均按重量计相对于a + b + c的重量之和,并且其中所述组合物包含非薄片颗粒或当与水性流体接触时形成非薄片颗粒。当组分b)为0%时,则组分a)包含至少两个结构形成两亲物。本发明还提供了该组合物的药物组合物和包含该组合物的试剂盒,用于建立活性剂的药物制剂。
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