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A HIGHLY POROUS, FAST-DISINTEGRATING SOLID DOSAGE FORM AND ITS WAY OF MANUFACTURING COMPRISING THE PREPARATION OF A POWDER AND A FREEZEDRYING STEP
A HIGHLY POROUS, FAST-DISINTEGRATING SOLID DOSAGE FORM AND ITS WAY OF MANUFACTURING COMPRISING THE PREPARATION OF A POWDER AND A FREEZEDRYING STEP
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机译:多孔,快速分散的固体剂型及其制备方法,包括粉末的制备和冷冻步骤
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摘要
The invention relates to a method of manufacture of fast-disintegrating soliddosage forms, characterized in that one or more structure building componentsin mixed solid powder form are dosed into cavities of blister packs or moulds,the remaining components dissolved in water dosed and added to the powder toform a moistened, plasticized mass, frozen to below -20~C , and the watersublimed in high vacuum. In this way solid dosage forms are obtainable with asimilar porous structure as usually result from freeze-drying processes, butthe process requires much less water, which means considerably less time andless energy.
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