LYOPHILIZING INSULIN LIPOSOME POWDER, ORAL INSULIN COMPLEX PREPARATION, PREPARATION METHOD THEREFOR, AND USE THEREOF

摘要

A lyophilizing insulin liposome powder and oral insulin complex preparation for treatment of type II diabetes, and preparation method therefor. The lyophilizing insulin liposome powder according to the present invention is prepared in the following steps: to an aqueous HCl solution, adding insulin, and then adding a phosphate buffer solution and sodium cholate solution to give an aqueous mixture; co-dissolving cholesterol and lecithin in absolute ethyl alcohol and adding aqueous mannitol solution and sodium cholate solution, and homogenizing for 10-30 minutes, to give an oily mixture; uniformly mixing the aqueous mixture with the oily mixture and placing in a water bath at 2-6°C, subjecting to distillation under reduced pressure, to give a concentrate; and lyophilizing the concentrate.