Liposomes containing glycocholate as potential oral insulin delivery systems: preparation in vitro characterization and improved protection against enzymatic degradation

摘要

Background:Oral delivery of insulin is challenging and must overcome the barriers of gastric and enzymatic degradation as well as low permeation across the intestinal epithelium. The present study aimed to develop a liposomal delivery system containing glycocholate as an enzyme inhibitor and permeation enhancer for oral insulin delivery.