C2-FLUORO SUBSTITUTED PIPERAZINE LINKED PYRROLO2,1-C1,4 BENZODIAZEPINE DIMERS AND A PROCESS FOR THE PREPARATION THEREOF

摘要

The present invention provides a compounds of general formula IXa-d, useful as potential antitumour agents and pharmaceutical composition comprising these compounds exhibits binding affinity with calf thymus (CT) DNA at a molar ratio of 1:5 in aqueous sodium phosphate buffer at pH of 7.00. The present invention further provides a process for the preparation of C2-Fluoro substituted piperazine linked pyrrolo[2,1c][1-4], benzodiazepine of formula (IX).