Remarkable DNA binding affinity and potential anticancer activity of pyrrolo(2,1-c)(1,4)benzodiazepine-naphthalimide conjugates linked through piperazine side-armed alkane spacers.

摘要

A series of pyrrolobenzodiazepine-naphthalimide conjugates tethered through a piperazine ring system have been designed, synthesized, and evaluated for their anticancer activity. These new conjugates exhibit very high DNA binding affinity and cytotoxic activity against a number of cell lines.