SEMAPHORIN 7A INDUCED LUNG FIBROGENESIS OCCURS IN A CD4-DEPENDENT, MACROPHAGE DEPENDENT MANNER

摘要

The present invention provides methods of treating a mammal diagnosed with, or at risk for developing, pathogenic fibrosis, particularly pulmonary fibrosis. The method of the invention comprises administering to the mammal a compound or composition which modulates a target, such as Cofilin-1 and/or Plexin CI. The method of the invention also comprises administering to the mammal a compound or composition which inhibits a lymphocyte that expresses Sema 7a.