CELL KILLING FUSION PEPTIDE EXHIBITING TUMOR CELL-SPECIFIC NECROSIS INDUCTION AND TUMOR REGRESSION

摘要

The present invention relates to a cell killing peptide, and more particularly, to a cell killing CKP fusion peptide (CTD7:CKP) in which a cell killing peptide (CKP), and 10 amino acids of MTD sites of Noxa protein for inducing cell death are hybridized with 7 amino acids for targeting tumor cells. According to the present invention, while the cell killing CKP fusion peptide strongly induces necrosis in various tumor cell lines (such as HeLa, HCT116, MCF-7, A549, HJAB, CT26, and PC3), the cell killing CKP fusion peptide does not exhibit a cell regression effect on a normal cell but exhibits a strong tumor regression effect in a mouse tumor model using laboratory animals. Therefore, the cell killing CKP fusion peptide can be widely used in the human body for treating various diseases which require cell death, and particularly as an anticancer agent.