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Cell killing fusion peptide having cancer cell-specific nectrosis and tumor regression effects
Cell killing fusion peptide having cancer cell-specific nectrosis and tumor regression effects
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机译:具有癌细胞特异性坏死和肿瘤消退作用的细胞杀伤融合肽
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摘要
A cell-killing peptide, more specifically a cell-killing CKP fusion peptide (CTD7:CKP) is disclosed, wherein a cell-killing peptide (CKP) comprising 10 amino acids in MTD of Noxa protein causing cell death, and 7 amino acids targeting a cancer cell are fused. The cell-killing CKP fusion peptide induces strong cell necrosis at various cancer cell lines (HeLa, HCT116, MCF-7, A549, BJAB, CT26, PC3 and the like) and shows strong tumor regression effect at a mouse tumor model using experimental animals, but does not show apoptosis at normal cells. Therefore, it can be broadly used to human body for treating various diseases requiring cell death, particularly, as an anti-cancer drug.
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