PREPARATION METHOD OF AMOROLFINE HYDROCHLORIDE

摘要

A preparation method of amorolfine hydrochloride comprises: with N-methylpyrrolidone as a solvent, in the presence of a palladium catalyst and a base, reacting 4-iodo-tert-amyl benzene with 2-methallyl alcohol, to obtain 3-tert-amylphenyl-2-methyl propionic acid; in the presence of glacial acetic acid, with triacetoxy sodium borohydride as a reducing agent, subjecting the obtained 3-tert-amylphenyl-2-methyl propionic acid and cis-2,6-dimethyl morpholine to reductive amination, to obtain amorolfine; and converting amorolfine into amorolfine hydrochloride.