NATURAL PRODUCTS AS RETINOIC ACID RECEPTOR (RARS) EXCITOMOTORS AND USES THEREOF

摘要

Disclosed are natural products as retinoic acid receptor (RARs) excitomotors and the uses thereof. The marine natural products Luffariellolide and Manoalide are specific excitomotors of retinoic acid receptors (RARs), able to inhibit the growth of multiple tumor cells, including colon cancer cells with drug resistance to retinoic acid, by means of retinoic acid receptors.