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METHOD FOR SCREENING ANTI-HBV COMPOUNDS

机译:筛选抗乙肝病毒化合物的方法

摘要

The present invention provides a method for screening anti-HBV compounds. In the method, anti-HBV compounds are screened by using an HBV core protein C-terminal amino acid sequence as a drug target, the HBV core protein C-terminal amino acid sequence at least comprising STLPETTVVRRRDRGR. The method provided in the present invention can be used to screen and find anti-HBV replication active compounds that induce abnormal packaging of HBV core particles, and can also be used to detect activities of new antiviral drugs, which are obtained in other manners, directed to the targets, and used for treating viral hepatitis B.
机译:本发明提供了筛选抗HBV化合物的方法。在该方法中,通过使用HBV核心蛋白C末端氨基酸序列作为药物靶标来筛选抗HBV化合物,该HBV核心蛋白C末端氨基酸序列至少包含STLPETTVVRRRDRGR。本发明提供的方法可用于筛选和发现诱导HBV核心颗粒包装异常的抗HBV复制活性化合物,还可用于检测以其他方式获得的新抗病毒药物的活性。达到目标,并用于治疗病毒性乙型肝炎。

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